The vaccines

There are currently two vaccines which protect against HPV infection, which are called Gardasil and Cervarix.

  • Gardasil, produced by Sanofi Pasteur MSD, is designed to protect against four types of HPV:
    • 16 and 18 (high risk for cervical cancer)
    • 6 and 11 (these types do not cause cervical cancer, but they do cause 90% of genital warts)
  • Cervarix, produced by GlaxoSmithKline, is designed to protect against HPV types 16 and 18 only

Both vaccines are licensed in the UK. The NHS currently uses Gardasil to vaccinate girls.

There is also a third vaccine called Gardasil 9. This protects against high risk HPV types 16, 18, 31, 33, 45, 52 and 58, as well as HPV 6 and 11. Gardasil 9 has been approved for licensing by the Committee for Medicinal Products for Human Use of the European Medicines Agency. This vaccine is likely to be given its licence by the European Commission later this year. If it gains its licence it is likely that the department of health will ask the Joint Committee on Vaccination and Immunisation (JCVI) to look at whether it would be cost effective to use Gardasil 9 in place of Gardasil for the immunisation program as it offers protection against more HPV types.

The vaccination is free for all girls from the age of 11 in Scotland [1] and 12 in the rest of the UK up to their 18th birthday, but only girls aged 11 to 13 in Scotland and 12 to 13 in the rest of the UK will be routinely offered the vaccine. The vaccination is given to girls at this age because their immune systems are at their strongest before puberty begins and the vaccination works best when the immune system is strong.

Vaccines are given by an injection into the muscle, usually the upper arm. For routine vaccination of girls under the age of 15, two separate doses are needed. The second dose should be given anytime between six to 12 months after the first, but it can be given up to 24 months after. If a girl is likely to reach her 15th birthday during the immunisation schedule, she will get three doses, as the response to two doses is not as good in older girls. These doses are given at zero, two and six months.

HPV vaccination has been shown to prevent infection and abnormal cervical cell changes for at least 10 years, but modelling suggests it will last longer [2]. Ongoing studies will show how much longer young women will be protected for and whether booster shots will be required.

Both Gardasil and Cervarix protect against the two highest risk HPV types. However, unfortunately, women can be infected with more than one type of HPV. Having the vaccine will provide protection against 70% of all cervical cancers and it will also prevent most of the more serious precancerous cervical changes (classed as moderate or severe cervical abnormalities) [3] [4].

There is some evidence that the HPV vaccines provide cross protection for other types of HPV, which may mean that they have a higher protection level than first thought [5] [6]. Research indicates that the HPV vaccine could prevent two thirds of cervical cancers in women aged below 30 years old by 2025, but only if uptake of the HPV vaccination remains at or above 80% [7].


  1. NHS Health Scotland, 2014. Human Papillomavirus (HPV). Accessed: 19.05.2015.
  2. Cancer Research UK, 2014. HPV vaccines. Accessed: 19.05.2015.
  3. Paavonen J et al., 2009. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women. Lancet  374 (9686), 301–314. 
  4. Wheeler C et al., 2009. The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in sexually active women aged 16-26 years. Journal of Infectious Disease 199 (7), 936–944.
  5. Szarewski A, 2008. HPV vaccines: peering through the fog. Journal of Family Planning and Reproductive Health Care 34 (4), 207–209.
  6. Kavanagh K et al., 2014. Introduction and sustained high coverage of the HPV bivalent vaccine leads to a reduction in prevalence of HPV 16/18 and closely related HPV types. British Journal of Cancer 110 (11), 2804–2811.
  7. Cuzick J et al, 2010. Predicted impact of vaccination against human papillomavirus 16/18 on cancer incidence and cervical abnormalities in women aged 20–29 in the UK. British Journal of Cancer 102, 933–939. 
Date last updated: 
21 May 2015
Date due for review: 
21 May 2017

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