A trial of chemotherapy before chemoradiation for cervical cancer (INTERLACE)

Cancer Research UK are offering the opportunity for women affected by cervical cancer to try a new treatment regime where chemotherapy is given before chemoradiation. The trial is available across the UK at various sites. When you make contact, the team can specific which locations are available.


Start: 27/09/2012
End: TBC

Who can enter
You may be able to enter this trial if:

  • You have cervical cancer that is larger than 4cm across and histologically confirmed as FIGO stage Ib2 up to 4a (squamous, adeno or adenosquamous carcinoma of the cervix) except those with disease extending to the lower third of the vagina). Patients with FIGO stage IB1 and positive lymph nodes are also eligible
  • Your doctors think chemoradiation is the best treatment for you
  • You are well enough to carry out all your normal activities, apart from heavy physical work (performance status of 0 or 1)
  • You have satisfactory blood test results
  • You are at least 18 years old
  • You are willing to use reliable contraception during the trial if there is any chance you could become pregnant

You cannot enter this trial if you:

  • Have cancer that has spread to other parts of your body (stage 4B) or to the lower third of your vagina
  • Have cancer that is blocking one of the tubes between your kidneys and your bladder (the ureters) which has made the kidney waterlogged (hydronephrosis) – you may be able to take part if this has been successfully treated
  • Have had another cancer in the last 10 years apart from basal cell skin cancer
  • Have ever had another cancer in the area between your hip bones (the pelvis)
  • Have already had radiotherapy to your pelvis
  • Have bowel conditions called Crohn’s disease or ulcerative colitis
  • Have certain heart problems – the trial team can advise you about this
  • Are HIV positive or have tuberculosis (TB)
  • Are pregnant or breastfeeding

You can find more details on their website: www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-of-chemotherapy-before-chemoradiation-for-cervical-cancer-interlace




Date last updated: 
04 Nov 2016